Colorectal cancer (CRC) has long been associated with alterations in the gut microbiome, including enrichment of Bacteroides fragilis. However, the mechanistic basis underlying this association remains incompletely understood. Recent research has identified distinct prophage infections within CRC-associated strains of B. fragilis, suggesting that bacteriophage integration may alter bacterial behavior and pathogenic potential.
This lecture reviews emerging evidence linking prophage carriage to colorectal cancer–associated microbial dysbiosis. We examine how prophages integrate into bacterial genomes, how they may modify bacterial gene expression, and how these alterations could influence inflammation, toxin production, and tumor microenvironment interactions. The session also discusses broader implications for microbiome research, biomarker development, and future therapeutic strategies.
This lecture is designed to provide clinicians and healthcare professionals with a mechanistic understanding of how bacteriophages may contribute to disease processes beyond classical bacterial pathogenicity models.
Study Objectives:
* Describe the role of gut microbiome dysbiosis in colorectal cancer and the association of Bacteroides fragilis with CRC.
* Interpret recent research findings linking prophage-enriched bacterial strains with colorectal cancer.
* Evaluate the potential implications of prophage-associated microbiome alterations for diagnostics, biomarkers, and therapeutic interventions.
- Describe the role of gut microbiome dysbiosis in colorectal cancer and the association of Bacteroides fragilis with CRC.
- Interpret recent research findings linking prophage-enriched bacterial strains with colorectal cancer.
- Evaluate the potential implications of prophage-associated microbiome alterations for diagnostics, biomarkers, and therapeutic interventions.
Write A New Comment
0 Comments